Discomfort can be so severe that you may not feel like eating much and subsequently consume fewer calories. The most common symptoms are vomiting, diarrhea, and nausea, which affect anywhere from 2 to 63 percent of people on the drug. “Some people who take metformin may experience gastrointestinal side effects like nausea and diarrhea,” says Rahaf Al Bochi, RDN, a Baltimore-based media spokesperson for the Academy of Nutrition and Dietetics and the owner of Olive Tree Nutrition.Īccording to a study published in the April–June 2017 Journal of Research in Pharmacy Practice, gastrointestinal side effects are a primary complaint from those who receive metformin tablets in their original formulation. Then there’s the possibility that the drug’s side effects can affect your food intake. Emerging research reported in journals including Current Obesity Reports suggests metformin may also lead to weight loss as a result of changes in the appetite centers of the brain, shifts in the gut microbiome, and reversal of metabolic changes that usually happen with age. Researchers found that hunger levels in the metformin group were significantly lower, especially so with the 1,700 mg dose compared with the lower metformin dose or placebo.Īnother study, published in May 2020 in the journal Diabetes Care, found that when participants increased their metformin dose by 1,000 mg or more, they lost significantly more weight than those who didn’t change their metformin dose or decrease their dose. Participants received a meal test on each third day and rated their hunger level before eating. In one small study, 12 women with obesity and type 2 diabetes who were not taking insulin were randomly given two dose levels of metformin - 850 milligrams (mg) or 1,700 mg - or a placebo three times a day for three days, with each participant going through the study three times so they had each dose and the placebo. The relationship between metformin and weight is unclear, but several theories provide possible explanations for weight fluctuations.įor example, metformin may affect hunger cues. This, of course, is the end goal of any diabetes treatment.Īs the medication helps your body reduce your overall blood sugar levels and restore your ability to respond to insulin, you’ll not only feel better, but you may reduce the risk of future complications of high blood sugar, such as heart disease, kidney damage, nerve damage or diabetic neuropathy, and eye damage (clinically called retinopathy), the Cleveland Clinic notes. There’s no cure for type 2 diabetes, but the right combination of medication and a healthy lifestyle can stabilize blood sugar levels, according to the Mayo Clinic, and in some cases even put type 2 diabetes in remission, according to a study published in Nutrients in April 2019. When insulin works better - and insulin sensitivity improves - a person’s insulin levels are lower than they would be otherwise.” “It also helps a hormone called insulin to work better by helping muscles use glucose in a more efficient manner. ![]() “ has been considered a first-line medication in the treatment of type 2 diabetes, and it mainly acts by lowering the amount of glucose released by the liver,” says Minisha Sood, MD, a board-certified endocrinologist in New York City. Food and Drug Administration (FDA) has approved to treat high blood sugar, or hyperglycemia, in people with type 2 diabetes. Metformin is a common type 2 diabetes drug that the U.S.
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